In the past decades, an enormous amount of precious information has been collected about molecular and genetic characteristics of cancer. This knowledge is mainly based on a reductionistic approach, meanwhile cancer is widely recognized to be a ‘system biology disease’. The behavior of complex physiological processes cannot be understood simply by knowing how the parts work in isolation. There is not solely a matter how to integrate all available knowledge in such a way that we can still deal with complexity, (...) but we must be aware that a deeply transformation of the currently accepted oncologic paradigm is urgently needed. We have to think in terms of biological networks: understanding of complex functions may in fact be impossible without taking into consideration influences outside of the genome. Systems Biology involves connecting experimental unsupervised multivariate data to mathematical and computational approach than can simulate biologic systems for hypothesis testing or that can account for what it is not known from high-throughput data sets. Metabolomics could establish the requested link between genotype and phenotype, providing informations that ensure an integrated understanding of pathogenic mechanisms and metabolic phenotypes and provide a screening tool for new targeted drug. (shrink)

Apart from the opposite semantic attitudes, the main difference between Late Medieval Realists and Nominalists lies in the antithetic evalutation of the nature and ontological status of essences. In the article a very interesting exemple of the medieval realist approach to the problem of essence, that of Walter Burley, is discussed. Because of Ockham's criticisms of the traditional realist conceptions, Burley's ontological convictions evolved over the years from a quite original version of the moderate realism inspired by Averroe's doctrine on (...) essence, to the radical (and somehow Platonic) form of realism proper to his final theories. (shrink)

The relationship between thought and reality was a focal point of Wyclif’s reflection. On the one hand, Wyclif believed that thought was linguistically constrained by its own nature; on the other hand, he considered thought to be related to reality in its elements and constitution. Hence he deemed language, thought, and external reality to be of the same logical coherence. Within this context, the theory of supposition was intended to explain the different roles that terms can have in relation to (...) language and the extra-mental world when they appear as extremes in propositions. Characteristically, his theory of supposition provides an account not only of the truth-values of a sentence, but also of its meaning; it is not therefore simply a theory of reference, but a sort of complex analysis of language viewed as a semiotic system whose unique interpretative model was reality itself. It gives clear evidence of Wyclif’s realist stance and of his conviction that any kind of linguistic and semantic features must be grounded on ontological structures. (shrink)

O presente artigo tem como objetivo, a partir de pesquisa bibliográfica desenvolvida no âmbito do doutorado em Educação, analisar as ideias pedagógicas de Johann Friedrich Herbart (1776-1841) e as possíveis contribuições do mesmo para a construção da masculinidade moderna. Herbart é um dos precursores da Pedagogia enquanto ciência organizada, associando diretamente os conhecimentos da filosofia, da educação e da psicologia para formular um aparato teórico que respondesse às transformações dos séculos XVII e XVIII, notadamente o Iluminismo Francês e a ascensão (...) da burguesia industrial, por isso, consideramos que o mesmo marca profundamente a Modernidade, tanto seu projeto pedagógico quanto sua concepção de masculinidade. Para melhor compreender a temática que propomos neste trabalho, dividimos o artigo em quatro seções: (a) na introdução localizamos os estudos sobre as masculinidades e o marco temporal deste trabalho; (b) em seguida expomos os percurso metodológico bibliográfico baseado no desenho circular de aproximações sucessivas às fontes; (c) na terceira analisamos o contexto histórico das formulações de Herbart, a organização sintética de suas ideias e sua proposta pedagógica; (d) por fim estabelecemos relações entre o projeto educacional do autor e as suas contribuições a masculinidade moderna. Concluímos que o pensamento de Herbat, pela abrangência de suas formulações, se configura como um dos pilares da masculinidade hegemônica. (shrink)

A. D. M. Walker; III*—Gratefulness and Gratitude, Proceedings of the Aristotelian Society, Volume 81, Issue 1, 1 June 1981, Pages 39–56, https://doi.org/10.1093.

A. D. M. Walker; III*—Gratefulness and Gratitude, Proceedings of the Aristotelian Society, Volume 81, Issue 1, 1 June 1981, Pages 39–56, https://doi.org/10.1093.

Moral theories which, like those of Plato, Aristotle and Aquinas, give a central place to the virtues, tend to assume that as traits of character the virtues are mutually compatible so that it is possible for one and the same person to possess them all. This assumption—let us call it the compatibility thesis—does not deny the existence of painful moral dilemmas: it allows that the virtues may conflict in particular situations when considerations associated with different virtues favour incompatible courses of (...) action, but holds that these conflicts occur only at the level of individual actions. Thus while it may not always be possible to do both what would be just and what would be kind or to act both loyally and honestly, it is possible to be both a kind and a just person and to have both the virtue of loyalty and the virtue of honesty. (shrink)

ANDREA: sincerity, conceptual review, philosophy.

The Problem of Perception offers two arguments against direct realism--one concerning illusion, and one concerning hallucination--that no current theory of ...

First published in 1991. Routledge is an imprint of Taylor & Francis, an informa company.

The paper examines a single, apparently simple argument for the existence of incompatibilities between the virtues as traits of character. This argument appeals not to empirical truths about human psychology or human nature but to the possibility of conflict between the exercise of different virtues in action. There are, for example, situations in which we can exercise the virtue of truthfulness only at the expense of not exercising the virtue of tact, as when we are asked a question to which (...) the straightforward answer will pain our questioner. The person who in these situations would give a straightforward answer possesses the virtue of truthfulness to a higher degree than the person who would respond more evasively, whereas the latter person possesses the virtue of tact to a higher degree than the former. But since the two responses are mutually exclusive, it follows that the degree to which we possess the virtue of truthfulness must, at least in some measure, correlate inversely with the degree to which we possess the virtue of tact. And similarly for many other pairs of virtues. My paper focusses on the two cardinal assumptions of this argument, viz., (i) that sometimes the exercise of one virtue can conflict with the exercise of another, and (ii) that the degree to which a person possesses a virtue correlates directly with the extent of its exercise, and defends both assumptions against a variety of objections which allege that, in different ways, they are insensitive to the complexity of the virtues. (shrink)

In this paper I want to examine a view of the Darwinian theory of evolution which was put forward fairly recently by A. R. Manser. His approach is of interest not only in itself, but also because it may be expanded to raise some fundamental questions about the nature of the science of biology in general. I shall not consider these further implications here, but shall concentrate on an examination of his thesis in the context in which it is raised. (...) My paper falls into two sections. In the first I shall state Manser's thesis and some of the arguments with which he supports it, and shall try to show how a series of objections raised by A. G. N. Flew and K. Connolly may be answered. In the second I shall offer on my own account a positive argument to provide a possible basis for his point of view, with the aim of indicating why the theory should be of the kind he suggests, and what form the study of evolution must take. (shrink)

At the risk of proving myself such a caviller, I want to ask a question which I have seldom heard raised, and which I have never seen discussed in anything that I have read about Berkeley. If I am right, it poses a problem for his immaterialism, not only different, but coming from a different direction, from those objections that are commonly levelled against him. If I am wrong, it will show how right Berkeley was to stress the difficulty of (...) using for one purpose our language which has become fashioned for another. At least, I hope that I shall not fail to be the ‘fair and ingenuous reader’for whom he asked. (shrink)

This paper considers the claim that perceptual experience is “transparent”, in the sense that nothing other than the apparent public objects of perception are available to introspection by the subject of such experience. I revive and strengthen the objection that blurred vision constitutes an insuperable objection to the claim, and counter recent responses to the general objection. Finally the bearing of this issue on representationalist accounts of the mind is considered.

In lieu of an abstract, here is a brief excerpt of the content:Humanism, Female Education, and Myth:Erasmus, Vives, and More's To CandidusA. D. CousinsWhen considering pleasure and chance as aspects of human experience, Thomas More sometimes gendered them female; that is to say, at times he represented them by drawing from the mythographies of Venus and of Fortune. But what did he suggest that actual women, as distinct from goddesses, were or should be or might become: what were his notions (...) of being a woman, of femaleness? Further, what did he suggest that women might contribute to the common weal? A useful way to start answering that question is to look at what More seems to have thought about educating women: in particular, women who were entering adult life—entering into what was agreed to be the major female role—by marrying for the first time and therefore newly taking upon themselves the management of a household. In one of his most ambitious Latin poems, as nowhere else, More wrote elaborately, concisely and problematically on the education of women who were in just those circumstances. My discussion attempts a repositioning of that poem, To Candidus: How to Choose A Wife A Poem in Iambic Dimeter Brachycatalectic (Versvs Iambici Dimetri Brachycatalectici ad Candidvm, Qvalis Vxor Deligenda). To make the attempt involves examining More's other Latin poems on women, as would be anticipated; however, I am mainly concerned here with affinities between To Candidus—then, to a lesser extent, some of More's associated Latin poems—and notions about female education that were or were to become part of the already long, and mostly male, debate about the nature of femaleness.1 To be [End Page 213] specific, I am chiefly concerned with affinities between More's poem and writings by Erasmus and by Vives on the education of prospective or of recent brides.Because the primary concern in my discussion is to clarify the relations between More's To Candidus and humanist notions on female education, especially notions put forward by two of More's humanist friends about young brides, I want initially to revisit the early modern debate on educating women, of course an important element of the wider debate about femaleness itself. One medieval and thence early modern idea on female education was that, in addition to what their mothers taught them, most women needed merely to receive religious and ethical instruction from their husbands, who would likewise instruct them in how to govern a household.2 After all, it was often pointed out, the household was women's natural domain: since, therefore, they would not normally engage with the world at large as would men—since, for example, they would not normally be educators, or writers, or politicians—women did not usually need the broad education appropriate to men.3 Assertion to the contrary was variously argued—and differences between or among those contrary assertions did not always depend on whether an author was male or female. In The Book of the City of Ladies (1405), a response to Boccaccio's De Mulieribus Claris and, perhaps unknowingly, also to Plutarch's The Virtues of Women, Christine de Pizan attempted to construct at once a refuge and a resource for [End Page 214] women, whom she recognized as having been misrepresented to themselves no less than to men throughout generations of misogynistic male fictions, ranging from satire to epic, from fable to history.4 Her City, in so far as it is a revisionist history of women, forms a textual space which does indeed offer a refuge as well as a resource, for Christine advocates that women, fulfilling their capabilities as women, aim at "cultivat[ing] virtue" and thereby gaining inclusion in the true, illustrious record of female achievement: membership of a textual community within which they will see themselves reflected and which is at one with the City of God.5 Inseparable from their seeking to do so, she emphasizes, will be their receiving education.6 Despite that emphasis—and despite her emphasizing that women are men's intellectual equals or, not infrequently, superiors—Christine nevertheless defends the concept that the domestic sphere and not the public is in general that "appropriate" to women.7... (shrink)

The claims that Dr. F. H. George makes on behalf of his machines are obscurely stated. Does he claim that a machine has been made and has actually produced a kind of response which is incalculable, given the specification to which it has been built and also the prescribed conditions, what is put in for the particular performance in question? “Incalculable” does not mean that nobody has bothered to calculate, but that somebody has bothered, that the calculations show that the (...) response in question is not among the calculated ones, that it is not chance or mechanical breakdown, but a specific response to something specific among the given conditions. If he could substantiate this claim, then I would reluctantly agree that some machines are cleverer and more thoughtful than I thought possible, and some men sillier and less thoughtful, for they deliberately design machines to do they know not what. (shrink)

There is a short answer to the question, whether scientific method can be applied to the study of the social relations of men, or, whether social sciences are possible; it is that these sciences exist and are in fact among the most ancient. Their success has perhaps been less startling than that of the physical sciences and they have perhaps been pursued with less enthusiasm. But there are reasons for this inherent in the nature of the social sciences, as I (...) shall try to show. (shrink)

I read Dr Cherniack’s article regarding do not resuscitate orders with interest.1 One of the problems with DNR orders is the patients’ assumption that if there is no DNR order they will survive resuscitative efforts. This of course is far from the truth. In my hospital these orders have been modified to “do not attempt to resuscitate” orders. One cannot be truly autonomous without being informed. Long term survival, as measured only by being alive, following inhouse cardiac arrest, is about (...) 15% over all age groups.2 In sick elderly patients over 70 years of age who survive a cardiac arrest, the subsequent hospital mortality approaches 100%. This fact, and concerns about harm, influence physicians’ attitudes, …. (shrink)

Positivists have excelled at destructive criticism. This criticism has been useful for pruning away absurd and superfluous theories but it is liable to be used to prune away everything else. The latest exponents, the Logical Positivists, are no less adept at criticism than their predecessors. The doctrines of this school have been surrounded with an air of mystery and inquirers have been frightened off by alarming technical apparatus. We all know that the Logical Positivists had proved that everybody else talked (...) nonsense, but we did not know what they themselves talked. Mr. A. J. Ayer's exposition of the doctrine, Language, Truth and Logic , is therefore welcome as it is simple. (shrink)

There are many possible ways of approach to philosophy, and there is also an impossible one, though one that has often been tried. That the philosopher can somehow spin his philosophy out of what he finds inside himself; that he has some private internal source of information in virtue of which he can decide what the Universe must be, without needing to take the trouble to look at it, is a belief that dies hard. But it is now dying, if (...) not dead, so that it is hardly necessary to refute it in detail. It should suffice to say that anybody who cherishes the belief will not find anything to interest him in what follows. I shall simply assume that the philosopher is, what we all are to some extent, a spectator of the world and of man's life in it and a commentator on what he sees. Where the philosopher differs from others is in the kind of interest he takes in the facts, not in the kind of facts that are there to be interested in. (shrink)

Everybody is to some extent pacific, as everybody prefers to attain his ends by peaceful means if he can. Even the most bloodthirsty militarist uses threats of war rather than war, if threats will do the work. Though most people prefer persuasion to violence and peace to war, they are prepared as a last resort to go to war and use violence, when that seems the only means to attaining some end they consider to be of vital importance. The one (...) hundred per cent pacifist, however, refuses to engage in war or support warlike action under any circumstances whatever. It is his case that I wish to consider. It is not my purpose to try to persuade anyone to be a pacifist or to be the opposite, but to point out that absolute pacifism carries with it certain logical consequences which are not particularly palatable. The opposed view, which I shall call the case for civic virtues, also carries unpalatable though different consequences. These two appear to be simple and clear-cut opposed views which I propose to state as fairly as I can, with their consequences. Certain qualifications and modifications will have to be considered later, but I do not think that there is actually any possible mean position which avoids the dilemma I am concerned to present. I shall state the case for civic virtue first and the pacifist case second. (shrink)

The purpose of this paper is to discuss and to relate to each other two topics: the admissibility of ignorance and mistake of fact as defences against negligence in crime; and the inadmissibility of ignorance and mistake of law as defences against criminal charges. I am in not concerned at all with torts negligence, only with criminal offences which can be committed negligently, where negligence suffices for liability, as in the law of homicide. This produces an untidy classification of elements, (...) one or other of which is needed to provide the required mens rea : intention, knowledge, recklessness and negligence. It is untidy, because the last does not belong on the same list as the other three, each of which can appropriately be called a state of mind in what we might say to be a positive sense, for each of them includes some degree of awareness of and/or attitude to relevant facts. If negligence is to be called a state of mind, it is so in a very stretched and negative way: to be told that a person was not attending to, thinking of or noticing something that he should have been is to be given some information, of a negative sort, about his state of mind, but it tells us very little, for it eliminates only one of an unlimited range of states of mind. His not attending, noticing, etc., is equally compatible with his daydreaming and with his concentrating hard on something else. If negligence requires inadvertence, as is commonly maintained, then there was a state of mind which the agent should have been in but was not; if, as I would argue, it does not require inadvertence, then there was a state of mind which the agent should have been in, and maybe he was not in it, maybe he was in it. would not require it; the definition runs, ‘a person is negligent if he fails to exercise such care, skill or foresight as a reasonable man in his situation would exercise’. However, that is only a proposal; at present advertent negligence is rare in criminal law, although common in torts.) On this view, the questions are whether his performance fell below scratch, what are to be the excusing conditions for such a performance, and if the answer to is yes, whether his performance was covered by the excusing conditions. (shrink)